Our research interests are in the cellular and molecular pathways that underlie pattern formation in the vertebrate embryo. We are particularly interested in how cells begin to acquire specific cell fates and morphologies early in development. Our most recent focus has been on the formation and differentiation of the musculature system. The vertebrate model system that we work with is the African clawed frog, Xenopus laevis. This system lends itself well to the study of embryology because the aquatic frog can be easily reared in a laboratory environment, the females lay hundred of eggs, the eggs are easily fertilized and development can be observed in a culture dish.
Domingo Lab Publications: #SFSU Undergraduate student; * SFSU Master’s student
Sabillo A, Ramirez J, Domingo CR. Making muscle: Morphogenetic movements and molecular mechanisms of myogenesis in Xenopus laevis. Semin Cell Dev Biol. 2016 Feb 5. pii: S1084-9521(16)30044-1. doi: 10.1016/j.semcdb.2016.02.006.
*Leal M.A., *Fickel SR, #Sabillo A, Ramirez J, *Martínez Vergara H, *Nave C, #Saw D, Domingo CR. The role of Sdf-1a signaling in Xenopus laevis somite morphogenesis. Dev Dyn. Nov 8. doi: 10.1002/dvdy.24092. PMID: 24357195. 2013.
Keller, R., Shih, J., and Domingo, C. The patterning and functioning of protrusive activity during convergence and extension of the Xenopus organizer. Development Suppl. "Gastrulation" (Stern, C. ed., 1992), 81-92, 1992.
Perris, R., Krotoski, D., Lallier, T., Domingo, C., Sorrell, J. M., and Bronner-Fraser, M. Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development. Development, 111:583-599, 1991.