Biology Department photograph montage

Domingo Lab

My lab research is focused on the cellular and molecular pathways that underlie pattern formation in the vertebrate embryo. We are particularly interested in how cells acquire specific cell fates and morphologies early in development.  Our most recent work focuses on the formation and differentiation of the musculature system. Our model system is the African clawed frog, Xenopus laevis as it lends itself well to the study of embryological processes given that embryos can be easily observed in a culture dish from the onset of fertilization to tadpole stages.

My education work focuses on strategies to increase the retention and graduation rate of students in STEM, with a particular focus on increasing diversity in the sciences. These efforts have led to improvements in teaching strategies as well as the development of innovative programmatic efforts that increase diversity across disciplines ranging from biology to computer science.

Resarch Publications:  #SFSU Undergraduate student; * SFSU Master’s student

*Martínez Vergara H. Ramirez J. *Rosing T, *Nave C., #Blandino R., #Saw D., *Saraf P., #Piexoto G., #Coombes C., *Adams M. and Domingo CR. 2018. miR-206 is required for changes in cell adhesion that drive muscle cell morphogenesis in Xenopus laevis. Developmental Biology. 438(2) 94-110. doi: 10.1016/j.ydbio.2018.03.021.

Sabillo A, Ramirez J, Domingo CR. Making muscle: Morphogenetic movements and molecular mechanisms of myogenesis in Xenopus laevis. Semin Cell Dev Biol. 2016 Feb 5. pii: S1084-9521(16)30044-1. doi: 10.1016/j.semcdb.2016.02.006.

*Leal M.A., *Fickel SR, #Sabillo A, Ramirez J, *Martínez Vergara H, *Nave C, #Saw D, Domingo CR. The role of Sdf-1a signaling in Xenopus laevis somite morphogenesis. Dev Dyn. Nov 8. doi: 10.1002/dvdy.24092. PMID: 24357195. 2013.

*Krneta-Stankic, V., # Sabillo, A. and Domingo, CR. The temporal and spatial patterning of axial myotome fibers in Xenopus laevis. Dev Dyn, 239:1162-1177. 2010.

*Chu, FH., Afonin, B., Gustin, JK., #Bost A., #Sanchez, M., and Domingo, CR. Embryonic cells depleted of b-catenin remain competent to differentiate into dorsal mesodermal derivatives. Dev Dyn,  236:3007-3019, 2007.

Daggett, D. F., Domingo, CR, Currie, P.D., and Amacher, S.L. Control of morphogenetic cell movements in the early zebrafish myotome. Dev Biol, 309:169-179, 2007.

Afonin, A., *Ho, M., Gustin, J.K., *Meloty-Kapella, C., and Domingo, CR. Cell behaviors associated with somite segmentation and rotation in Xenopus laevis. Dev Dyn, 235:3268-3279, 2006.

*Wunderlich, K., Gustin, J., and Domingo, CR.  Muscle specification in the Xenopus laevis-gastrulation stage embryo. Dev Dyn, 233:1348-1358, 2005.

*Dali, L.A., Gustin, J., *Perry, K. and Domingo, CR. Signals that instruct somite and myotome formation persist in the Xenopus laevis tailbud. Cells Tissues Organs, 172:1-12, 2002.

Domingo, CR. and R. Keller. Cells throughout the gastrula remain competent to respond to mesoderm inducing signals present during gastrulation in Xenopus laevis. Dev Biol, 225:226-240, 2000.

Domingo, C. and Keller, R. Induction of notochord cell intercalation behavior and differentiation by progressive signals in the gastrula of Xenopus laevis. Development, 121:3311-3321, 1995.

Keller, R., Shih, J., and Domingo, C. The patterning and functioning of protrusive activity during convergence and extension of the Xenopus  organizer. Development Suppl. "Gastrulation" (Stern, C. ed., 1992), 81-92, 1992.

Perris, R., Krotoski, D., Lallier, T., Domingo, C., Sorrell, J. M., and Bronner-Fraser, M. Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development. Development, 111:583-599, 1991.

Krotoski, D., Domingo, C., and Bronner-Fraser, M. Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo. J. Cell Biol, 103:1061-1071, 1986.

Education Publications

Owens, MT, Seidel, SB, Wong, M, [and 77 others] Domingo, CR, Schinske, JN, Tanner, KD. 2017 Classroom Sound Can Be Used To Classify Teaching Practices in College Science Courses. PNAS 114(12), 3085–3090doi: 10.1073/pnas.1618693114.

Estrada M, Eroy-Reveles A., Ben-Zeev A., Baird Jr T, Domingo C, Gómez CA, Bibbins-Domingo K, Parangan-Smith A and Márquez-Magaña L. 2017. Enabling full representation in science: the San Francisco BUILD project’s agents of change affirm science skills, belonging and community. BMC Proceedings, 11(Suppl 12):25 doi: 10.1186/s12919-017-0090-9.

M.T. Owens, G. Trujillo, S.B. Seidel, [and 63 others] C.R. Domingo, K.D. Tanner. Collectively Improving Our Teaching: Attempting Biology Department-wide Professional Development in Scientific Teaching. 2018. CBE: Life Sciences Education. March 1; 17(1):ar2.

A.E. Wilson, J.L. Pollock, I. Billick, C. Domingo, E. Fernandez-Figueroa, E. Nagy, T.D. Steury, A. Summers. Assessing science training programs: Structured undergraduate research programs make a difference. 2018. Bioscience, 68 (7) 529–534. doi:10.1093/biosci/biy052.

Ilmi Yoon, Pleuni Pennings, Anagha Kulkarni, Kaz Okada, Carmen Domingo. Promoting Inclusivity in Computing (PINC) via Computing Application Minor. 2018. American Society for Engineering Education. ASEE<!--EndFragment-->

Kulkarni A., Yoon I., Pennings PS, Okada K, and Domingo C. Promoting Diversity in Computing. 2018. In Proceedings of 23rd Annual ACM Conference on Innovation and Technology in Computer Science Education (ITiCSE’18). ACM, New York, NY, USA, 6 pages. https: //doi.org/10.1145/3197091.3197145.